Detalhe da pesquisa
1.
Predicting Tacrolimus Concentrations in the Skin of Adult Kidney Transplant Recipients: A Feasibility Study.
Transpl Int
; 37: 12019, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38323070
2.
Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer.
Bioorg Med Chem Lett
; 29(2): 216-219, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30503634
3.
SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling.
Exp Cell Res
; 370(2): 283-291, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29959912
4.
Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90).
Bioorg Med Chem Lett
; 28(8): 1357-1362, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29545103
5.
Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6).
Bioorg Med Chem Lett
; 28(15): 2636-2640, 2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945795
6.
Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193668
7.
Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents.
Bioorg Med Chem Lett
; 27(4): 967-972, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28082040
8.
Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds.
Antimicrob Agents Chemother
; 60(5): 3076-89, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26953199
9.
A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo.
Pharmacol Res
; 113(Pt A): 533-546, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27687956
10.
Fluorescent Probes for H2S Detection and Quantification.
Handb Exp Pharmacol
; 230: 291-323, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26162841
11.
SB1578, a novel inhibitor of JAK2, FLT3, and c-Fms for the treatment of rheumatoid arthritis.
J Immunol
; 189(8): 4123-34, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22962687
12.
Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts.
J Immunother Cancer
; 11(9)2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37678918
13.
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening.
Bioorg Med Chem Lett
; 22(12): 4023-7, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22591730
14.
2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1.
Bioorg Med Chem Lett
; 22(8): 2880-4, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22437109
15.
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.
Bioorg Med Chem Lett
; 19(3): 894-9, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19095445
16.
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.
Eur J Med Chem
; 184: 111755, 2019 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31627059
17.
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
Bioorg Med Chem Lett
; 18(5): 1725-9, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18255291
18.
Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131).
Eur J Med Chem
; 156: 344-367, 2018 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30015072
19.
Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat.
Eur J Med Chem
; 158: 593-619, 2018 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30243158
20.
Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome.
Front Microbiol
; 8: 746, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28496439